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comX [2018-02-23 19:10:14]
competence pheromone precursor, transfers cell density signal to ComP; triggers the production of surfactin
product
competence pheromone precursor
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]Gene
Coordinates
3,255,853 → 3,256,020
Phenotypes of a mutant
the mutation suppresses the mucoid phenotype of ''[gene|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]'' or ''[gene|FE56753D061344B0F10A6523F49C5C7356AA40B6|motB]'' mutants due to loss of [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU] phosphorylation and concomitant reduced expression of the ''[gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]'' operon [Pubmed|24296669]The protein
Modification
is synthesized as an inactive precursor, cleaved, and modified (prenylated) on W53 by [protein|FDACEF9DDC3BEA4EB013AE67BC47ADA532F00205|ComQ] prior to excretion [Pubmed|28326143,22878193][SW|Localization]
secreted (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|FDACEF9DDC3BEA4EB013AE67BC47ADA532F00205|comQ]-[gene|60D6EB02923D9ADE88F61A8CBBD882BA8BDD457E|comX]-[gene|5A00E233F0B5A0DAB18D2ECC55527F1911987F86|comP]-[gene|7832489F11F606BCF637EC23BAAB41AD10237EBB|comA]-[gene|015989AAB862E418C944AB35DA3605863F059CE9|yuxO]
description
[Pubmed|22383849]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|2507523], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]view in new tabBiological materials
Mutant
BKE31700 (Δ[gene|60D6EB02923D9ADE88F61A8CBBD882BA8BDD457E|comX]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE31700 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AATTAGGTCTTGCATCTTGT, downstream forward: _UP4_GGTGATTAATAGGTGGATTABKK31700 (Δ[gene|60D6EB02923D9ADE88F61A8CBBD882BA8BDD457E|comX]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK31700 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AATTAGGTCTTGCATCTTGT, downstream forward: _UP4_GGTGATTAATAGGTGGATTAReferences
Reviews
Original publications
16407988,11133937,12067344,19202088,14679219,15564679,17240141,19605685,1715859,22878193,24296669,22511326,21636272,24425772,24788106,25757097,26276536,26787913,26927849,29038467